VPREB1: VPREB1 Protein | VPREB1 Antibody

VPREB1 Gene family

VPREB1 Background

VPREB1 gene, a component of the surrogate light chain of the pre-B-cell receptor (pre-BCR), have been observed in childhood B-cell acute lymphoblastic leukemia (B-ALL), and have been suggested to result from recombination activating gene (RAG) activation. Studies show that a low copy number of the VPREB1 gene is related to the pathogenesis of RA and other autoimmune disorders. Moreover, the VpreB1 can act as an enhancer to ensure developmental stage-specific expression of a reporter gene in B lymphocytes in vivo.

Reference for VPREB1

  • Mangum DS, et al. (2014) Vpreb1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia. Leukemia 28(1), 216-220.
  • Yim SH, et al. (2011) The potential role of vpreb1 gene copy number variation in susceptibility to rheumatoid arthritis. Mol Immunol 48(11), 1338-1343.
  • Licence S, et al. (2003) The vpreb1 enhancer drives developmental stage-specific gene expression in vivo. Eur J Immunol 33(4), 1117-1126.

VPREB1 Protein

VPREB1 protein function

Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.

VPREB1 protein expression

Tissue specificity

Only expressed by pre-B-cells.

VPREB1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    145.00
  • Mass (Da)
    16.00

VPREB1 Antibody

There are 1 VPREB1 antibodies which are validated in multiple tissues with various applications, including WB. There are 1 VPREB1 antibody for WB. Among all these VPREB1 antibodies, there are 1 anti-VPREB1 rabbit polyclonal antibodies . All the VPREB1 anbodies are produced in house and all are in stock. VPREB1 antibody customerized service is available.

VPREB1 Gene

VPREB1 gene / cDNA is a protein-coding gene which located on 22q11.22. The VPREB1 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, and rat.30 organisms have orthologs with human gene VPREB1.