VISTA Information: VISTA Protein, VISTA Antibody and VISTA Gene

VISTA Gene family

VISTA Protein

VISTA protein function

Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}.

VISTA protein expression

Tissue specificity

Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues.

VISTA protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    311.00
  • Mass (Da)
    33.00

VISTA Antibody

There are 9 VISTA antibodies which are validated in multiple tissues with various applications, including FCM, IHC-P, ELISA, ICC/IF. There are 1 VISTA antibody for FCM, 3 VISTA antibody for IHC-P, 6 VISTA antibody for ELISA, 2 VISTA antibody for ICC/IF. Among all these VISTA antibodies, there are 2 anti-VISTA mouse monoclonal antibodies , 7 anti-VISTA rabbit polyclonal antibodies . All the VISTA anbodies are produced in house and all are in stock. VISTA antibody customerized service is available.

VISTA Gene

Vsir gene / cDNA is a protein-coding gene which located on 10q22.1. The VSIR gene is conserved in chimpanzee, cow, mouse, rat, chicken, zebrafish, and frog.229 organisms have orthologs with human gene VSIR.