TRAIL/TNFSF10 Gene Sequence, Family, Fuction and Expression Information
TRAIL/TNFSF10 cDNA / Gene Overview
TNFSF10 gene / cDNA is a protein-coding gene which located on 3q26. The TNFSF10 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.203 organisms have orthologs with human gene TNFSF10.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
TRAIL/TNFSF10 cDNA / Gene Sequence
LOCUS NM_001190942 1805 bp mRNA linear PRI 05-AUG-2018
Homo sapiens TNF superfamily member 10 (TNFSF10), transcript variant 2, mRNA.
This sequence information is just for reference only.