TRAIL/TNFSF10 Gene Sequence, Family, Fuction and Expression Information

TRAIL/TNFSF10 cDNA / Gene Overview

TNFSF10 gene / cDNA is a protein-coding gene which located on 3q26. The TNFSF10 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.203 organisms have orthologs with human gene TNFSF10.

TRAIL/TNFSF10 cDNA / Gene Function

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

TRAIL/TNFSF10 cDNA / Gene Sequence

LOCUS
LOCUS NM_001190942 1805 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens TNF superfamily member 10 (TNFSF10), transcript variant 2, mRNA.
ACCESSION
NM_001190942
VERSION
NM_001190942.1

This sequence information is just for reference only.

TRAIL/TNFSF10 Family & Reagents

TRAIL/TNFSF10 Gene family reagents (CD molecules)

Approved Symbol Reagent list
NECTIN3
CD96
PROM1
ENPP3
CD81
FCGR3B
TFRC
IL6R
TREM1
DPP4
Approved Symbol Reagent list
BTN3A1
LAIR2
SIGLEC6
KIR2DL3
FCER2
EpCAM
PROCR
MUC1
GGT1
CD80

TRAIL/TNFSF10 Gene family reagents (Tumor necrosis factor superfamily)

Approved Symbol Reagent list
CD40LG
FASLG
LTB
TNFSF11
TNFSF13
TNFSF14
TNFSF18
TNFSF8
Approved Symbol Reagent list
CD70
LTA
TNF
TNFSF12
TNFSF13B
TNFSF15
TNFSF4
TNFSF9

TRAIL/TNFSF10 cDNA / Gene Alias

  • Apo-2L
  • CD253
  • TL2
  • TRAIL

TRAIL/TNFSF10 cDNA / Gene Expression

Ubiquitous expression in lung (RPKM 64.9), placenta (RPKM 44.9) and 21 other tissues