This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]
TIGIT cDNA / Gene Sequence
LOCUS NM_173799 2978 bp mRNA linear PRI 08-JUL-2018
Homo sapiens T cell immunoreceptor with Ig and ITIM domains (TIGIT), mRNA.
This sequence information is just for reference only.