TIGIT: TIGIT Protein | TIGIT Antibody

TIGIT Gene family

TIGIT Background

TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-1 and diminished the production of IL-12p4. In addition, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition.

Reference for TIGIT

  • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 36:40-45.
  • Bechtel S., et al., (2007), The full-ORF clone resource of the German cDNA consortium.BMC Genomics 8:399-399.
  • Yu X., Harden K., et al.,(2009), The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat. Immunol. 10:48-57.

TIGIT Protein

TIGIT protein function

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. {ECO:0000269|PubMed:19011627}.

TIGIT protein expression

Tissue specificity

Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level).

TIGIT protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    244.00
  • Mass (Da)
    26.00

TIGIT Antibody

There are 5 TIGIT antibodies which are validated in multiple tissues with various applications, including ELISA, IHC-P. There are 5 TIGIT antibody for ELISA, 1 TIGIT antibody for IHC-P. Among all these TIGIT antibodies, there are 1 anti-TIGIT mouse monoclonal antibodies , 4 anti-TIGIT rabbit polyclonal antibodies . All the TIGIT anbodies are produced in house and all are in stock. TIGIT antibody customerized service is available.

TIGIT Gene

TIGIT gene / cDNA is a protein-coding gene which located on 3q13.31. The TIGIT gene is conserved in chimpanzee, dog, cow, mouse, and rat.123 organisms have orthologs with human gene TIGIT.