TGFBR3 Gene Sequence, Family, Fuction and Expression Information
TGFBR3 cDNA / Gene Overview
TGFBR3 gene / cDNA is a protein-coding gene which located on 1p22.1. The TGFBR3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.239 organisms have orthologs with human gene TGFBR3.
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
TGFBR3 cDNA / Gene Sequence
LOCUS NM_003243 6475 bp mRNA linear PRI 24-JUN-2018