TGFBR3 Gene Sequence, Family, Fuction and Expression Information

TGFBR3 cDNA / Gene Overview

TGFBR3 gene / cDNA is a protein-coding gene which located on 1p22.1. The TGFBR3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.239 organisms have orthologs with human gene TGFBR3.

TGFBR3 cDNA / Gene Function

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]

TGFBR3 cDNA / Gene Sequence

LOCUS
LOCUS NM_003243 6475 bp mRNA linear PRI 24-JUN-2018
DEFINITION
Homo sapiens transforming growth factor beta receptor 3 (TGFBR3), transcript variant 1, mRNA.
ACCESSION
NM_003243
VERSION
NM_003243.4

This sequence information is just for reference only.

TGFBR3 Family & Reagents

Gene family

TGFBR3 Gene family reagents (Proteoglycans)

Approved Symbol Reagent list
CD44
Approved Symbol Reagent list
SRGN

TGFBR3 cDNA / Gene Alias

  • betaglycan
  • betaglycan proteoglycan
  • BGCAN

TGFBR3 cDNA / Gene Expression

Ubiquitous expression in fat (RPKM 40.0), ovary (RPKM 37.4) and 23 other tissues