RSPO1 Gene Sequence, Family, Fuction and Expression Information

RSPO1 cDNA / Gene Overview

RSPO1 gene / cDNA is a protein-coding gene which located on 1p34.3. The RSPO1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.232 organisms have orthologs with human gene RSPO1.

RSPO1 cDNA / Gene Function

This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

RSPO1 cDNA / Gene Sequence

LOCUS
LOCUS NM_173640 2333 bp mRNA linear PRI 06-JAN-2006
DEFINITION
Homo sapiens R-spondin homolog (Xenopus laevis) (RSPO1), transcript variant 2, mRNA.
ACCESSION
NM_173640
VERSION
NM_173640.1

This sequence information is just for reference only.

RSPO1 Family & Reagents

Gene family

RSPO1 Gene family reagents (Endogenous ligands)

Approved Symbol Reagent list
F2
RAC2
RAC1
CALM2
PSAP
Spp1
CXCL3
CXCL11
CCL15
CXCL2
Approved Symbol Reagent list
VTN
BMP5
vWF
RSPO3
BMP4
CCL20
IL1RN
GAL
CXCL10
AGT

RSPO1 cDNA / Gene Alias

  • FLJ40906
  • RSPONDIN

RSPO1 cDNA / Gene Expression

Biased expression in endometrium (RPKM 16.2), skin (RPKM 2.3) and 5 other tissues