RSPO1 Gene Sequence, Family, Fuction and Expression Information
RSPO1 cDNA / Gene Overview
RSPO1 gene / cDNA is a protein-coding gene which located on 1p34.3. The RSPO1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.232 organisms have orthologs with human gene RSPO1.
This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
RSPO1 cDNA / Gene Sequence
LOCUS NM_173640 2333 bp mRNA linear PRI 06-JAN-2006