REG4 Information: REG4 Protein, REG4 Antibody and REG4 Gene

REG4 Gene family

REG4 Protein

REG4 protein function

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. {ECO:0000269|PubMed:12819006, ECO:0000269|PubMed:20692269}.

REG4 protein expression

Tissue specificity

Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in normal colon. Preferentially expressed in mucinous tumors and in some cases neuro-endocrine tumors. Expressed in mucus-secreting cells and enterocyte-like cells. In small intestine expressed at the basal perinuclear zone of goblet cells.

Induction

Up-regulated by mucosal injury from active Crohn's disease or ulcerative colitis. Up-regulated in colorectal tumors. Up-regulated in epithelial cells at regenerating margins of peptic ulcers in the stomach and duodenum.

REG4 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    158.00
  • Mass (KDa)
    18.00

REG4 Antibody

There are 9 REG4 antibodies which are validated in multiple tissues with various applications, including ELISA(Det), ELISA(Cap), ELISA, IHC-P. There are 1 REG4 antibody for ELISA(Det), 1 REG4 antibody for ELISA(Cap), 5 REG4 antibody for ELISA, 4 REG4 antibody for IHC-P. Among all these REG4 antibodies, there are 2 anti-REG4 mouse monoclonal antibodies , 2 anti-REG4 rabbit monoclonal antibodies , 5 anti-REG4 rabbit polyclonal antibodies . All the REG4 anbodies are produced in house and all are in stock. REG4 antibody customerized service is available.

REG4 Gene

REG4 gene / cDNA is a protein-coding gene which located on 1p12. The REG4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.157 organisms have orthologs with human gene REG4.