Properdin Protein Overview: Sequence, Structure, Function and Protein Interaction

Properdin Protein Overview

Properdin reagents

Properdin (factor P) is a plasma protein that is active in the alternative complement pathway of the innate immune system. It is a positive regulatory factor that binds to many microbial surfaces to stabilize the C3b,Bb convertase. The C3b,Bb convertase then rapidly cleaves more C3 to C3b, which acts either as an opsonin or to reinitiate the pathway in an amplification loop that proceeds on the bacterial cell, but not on the host cell (Janeway et al., 2001). In the alternative pathway, C3 is thus activated through factor B, factor D, and properdin P, under the control of factors I and H (Fearon and Austen, 1980). Deficiency of properdin is associated in particular with a heightened susceptibility to Neisseria species (Janeway et al., 2001).

Properdin protein name

Recommended name

Properdin Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 28-469 Properdin.

Molecular weight (Da)


Theoretical pI


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