Properdin Gene Sequence, Family, Fuction and Expression Information
Properdin cDNA / Gene Overview
CFP cDNA / gene is a gene with protein product which located on Xp11.23. The CFP gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish. 154 organisms have orthologs with human gene CFP.
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]
Properdin cDNA / Gene Sequence
HUMPROP 1543 bp mRNA linear PRI 11-FEB-2002
Homo sapiens complement omponent properdin mRNA, complete cds.
This sequence information is just for reference only.