PI3 Kinase p110 beta/PIK3CB Information: PI3 Kinase p110 beta/PIK3CB Protein, PI3 Kinase p110 beta/PIK3CB Antibody and PI3 Kinase p110 beta/PIK3CB Gene

PI3 Kinase p110 beta/PIK3CB Gene family

PI3 Kinase p110 beta/PIK3CB Protein

PI3 Kinase p110 beta/PIK3CB protein function

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. {ECO:0000269|PubMed:18594509, ECO:0000269|PubMed:18755892, ECO:0000269|PubMed:21030680, ECO:0000269|PubMed:21383062}.

PI3 Kinase p110 beta/PIK3CB protein expression

Tissue specificity

Expressed ubiquitously.

PI3 Kinase p110 beta/PIK3CB protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,070.00
  • Mass (KDa)
    122.00

PI3 Kinase p110 beta/PIK3CB Antibody

There are 1 PI3 Kinase p110 beta/PIK3CB antibodies which are validated in multiple tissues with various applications, including IHC-P, ICC/IF. There are 1 PI3 Kinase p110 beta/PIK3CB antibody for IHC-P, 1 PI3 Kinase p110 beta/PIK3CB antibody for ICC/IF. Among all these PI3 Kinase p110 beta/PIK3CB antibodies, there are 1 anti-PI3 Kinase p110 beta/PIK3CB rabbit polyclonal antibodies . All the PI3 Kinase p110 beta/PIK3CB anbodies are produced in house and all are in stock. PI3 Kinase p110 beta/PIK3CB antibody customerized service is available.

PI3 Kinase p110 beta/PIK3CB Gene

PIK3CB gene / cDNA is a protein-coding gene which located on 3q22.3. The PIK3CB gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.235 organisms have orthologs with human gene PIK3CB.