PIK3CA Protein Overview: Sequence, Structure, Function and Protein Interaction

PIK3CA Protein Overview

PIK3CA reagents

PIK3CA protein family

Belongs to the PI3/PI4-kinase family.

PIK3CA protein name

Recommended name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Short name
PI3-kinase subunit alpha||PI3K-alpha||PI3Kalp
Aliases
PI3K
Alternative name
Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha Phosphoinositide-3-kinase catalytic alpha polypeptide Serine/threonine protein kinase PIK3CA

PIK3CA Protein Sequence

Species Human PIK3CA protein
Length 1068
Mass (Da) 124284
Sequence Human PIK3CA protein sequence
Species Mouse PIK3CA protein
Length 1068
Mass (Da) 124412
Sequence Mouse PIK3CA protein sequence
Species Rat PIK3CA protein
Length 1068
Mass (Da) 124354
Sequence Rat PIK3CA protein sequence

PIK3CA Protein Molecular Weight & PI

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-1068 Phosphatidylinositol 4,5-bisphosphate 3-

Molecular weight (Da)

124284.1

Theoretical pI

6.88

PIK3CA Protein Structure

p110alpha/p85alpha with compound 5
Deposited
2015-09-23   Released:  2016-01-27
Deposition Author(s)
Heffron, T.P., Heald, R.A., Ndubaku, C., Wei, B.Q., Augustin, M., Do, S., Edgar, K., Eigenbrot, C., Friedman, L., Gancia, E., Jackson, P.S., Jones, G., Kolesnikov, A., Lee, L.B., Lesnick, J.D., Lewis, C., McLean, N., Mortle, M., Nonomiya, J., Pang, J., Price, S., Prior, W.W., Salphati, L., Sideris, S., Staben, S., Steinbacher, S., Tsui, V., Wallin, J., Sampath, D., Olivero, A.
Organism(s)
Bos taurus, Homo sapiens
Expression System
Spodoptera frugiperda
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
3.0000 Å
R-Value Free
0.218
R-Value Work
0.181
5DXH From PDB

Human PIK3CA protein Secondary structure

PIK3CA Protein Interaction

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