PIK3CA Information: PIK3CA Protein, PIK3CA Antibody and PIK3CA Gene

PIK3CA Gene family

PIK3CA Protein

PIK3CA protein function

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity). {ECO:0000250|UniProtKB:P42337, ECO:0000269|PubMed:21708979, ECO:0000269|PubMed:26593112}.

PIK3CA protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,068.00
  • Mass (KDa)
    124.00

PIK3CA Antibody

There are 1 PIK3CA antibodies which are validated in multiple tissues with various applications, including WB, ICC/IF. There are 1 PIK3CA antibody for WB, 1 PIK3CA antibody for ICC/IF. Among all these PIK3CA antibodies, there are 1 anti-PIK3CA rabbit polyclonal antibodies . All the PIK3CA anbodies are produced in house and all are in stock. PIK3CA antibody customerized service is available.

PIK3CA Gene

PIK3CA gene / cDNA is a protein-coding gene which located on 3q26.32. The PIK3CA gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog.223 organisms have orthologs with human gene PIK3CA.