P38 Gamma/MAPK12 Protein Overview: Sequence, Structure, Function and Protein Interaction

P38 Gamma/MAPK12 Protein Overview

Activation of members of the mitogen-activated protein kinase (MAPK) family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases (SAPKs; see 601335) are one subclass of MAPKs.

P38 Gamma/MAPK12 protein family

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

P38 Gamma/MAPK12 protein name

Recommended name
Mitogen-activated protein kinase 12
Short name
MAP kinase 12||MAPK 12||ERK-6||MAP kinase p38
ERK6, p38gamma, PRKM12, SAPK-3
Alternative name
Extracellular signal-regulated kinase 6 Mitogen-activated protein kinase p38 gamma Stress-activated protein kinase 3

P38 Gamma/MAPK12 Gene family protein

P38 Gamma/MAPK12 Protein Sequence

Species Human P38 Gamma/MAPK12 protein
Length 367
Mass (Da) 41940
Sequence Human P38 Gamma/MAPK12 protein sequence
Species Mouse P38 Gamma/MAPK12 protein
Length 367
Mass (Da) 42043
Sequence Mouse P38 Gamma/MAPK12 protein sequence
Species Rat P38 Gamma/MAPK12 protein
Length 367
Mass (Da) 41985
Sequence Rat P38 Gamma/MAPK12 protein sequence

P38 Gamma/MAPK12 Protein Molecular Weight & PI

Mitogen-activated protein kinase 12 (EC (MAP kinase 12) (MAPK 12) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-367 Mitogen-activated protein kinase 12.

Molecular weight (Da)


Theoretical pI


P38 Gamma/MAPK12 Protein Structure

1999-05-17   Released:  2000-05-17
Deposition Author(s)
Bellon, S., Fitzgibbon, M.J., Fox, T., Hsiao, H.M., Wilson, K.P.
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
2.4000 Å
R-Value Free
R-Value Work
1CM8 From PDB

Human P38 Gamma/MAPK12 protein Secondary structure

P38 Gamma/MAPK12 Protein Interaction

Recombinant P38 Gamma/MAPK12 Protein Feature

P38 Gamma/MAPK12 Protein, Human, Recombinant

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Kinase activity untested

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