P38 Gamma/MAPK12 Information: P38 Gamma/MAPK12 Protein, P38 Gamma/MAPK12 Antibody and P38 Gamma/MAPK12 Gene

P38 Gamma/MAPK12 Gene family

P38 Gamma/MAPK12 Protein

P38 Gamma/MAPK12 protein function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. {ECO:0000269|PubMed:10848581, ECO:0000269|PubMed:14592936, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:21172807, ECO:0000269|PubMed:8633070, ECO:0000269|PubMed:9430721}.

P38 Gamma/MAPK12 protein expression

Tissue specificity

Highly expressed in skeletal muscle and heart.

Induction

Expression of MAPK12 is down-regulation by MAPK14 activation.

P38 Gamma/MAPK12 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    367.00
  • Mass (KDa)
    41.00

P38 Gamma/MAPK12 Antibody

There are 1 P38 Gamma/MAPK12 antibodies which are validated in multiple tissues with various applications, including WB, ELISA, IP. There are 1 P38 Gamma/MAPK12 antibody for WB, 1 P38 Gamma/MAPK12 antibody for ELISA, 1 P38 Gamma/MAPK12 antibody for IP. Among all these P38 Gamma/MAPK12 antibodies, there are 1 anti-P38 Gamma/MAPK12 rabbit polyclonal antibodies . All the P38 Gamma/MAPK12 anbodies are produced in house and all are in stock. P38 Gamma/MAPK12 antibody customerized service is available.

P38 Gamma/MAPK12 Gene

MAPK12 gene / cDNA is a protein-coding gene which located on 22q13.33. The MAPK12 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.173 organisms have orthologs with human gene MAPK12.