NPC2 Information: NPC2 Protein, NPC2 Antibody and NPC2 Gene

NPC2 Protein

NPC2 protein function

Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport. {ECO:0000269|PubMed:17018531, ECO:0000269|PubMed:18772377, ECO:0000269|PubMed:18823126}.

NPC2 protein expression

Tissue specificity

Epididymis.

Induction

Down-regulated in response to enterovirus 71 (EV71) infection.

NPC2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    151.00
  • Mass (KDa)
    16.00

NPC2 Antibody

There are 12 NPC2 antibodies which are validated in multiple tissues with various applications, including ELISA, IHC-P, WB, IP, ELISA(Det), ELISA(Cap). There are 8 NPC2 antibody for ELISA, 4 NPC2 antibody for IHC-P, 2 NPC2 antibody for WB, 1 NPC2 antibody for IP, 1 NPC2 antibody for ELISA(Det), 1 NPC2 antibody for ELISA(Cap). Among all these NPC2 antibodies, there are 2 anti-NPC2 mouse monoclonal antibodies , 6 anti-NPC2 rabbit monoclonal antibodies , 4 anti-NPC2 rabbit polyclonal antibodies . All the NPC2 anbodies are produced in house and all are in stock. NPC2 antibody customerized service is available.

NPC2 Gene

NPC2 gene / cDNA is a protein-coding gene which located on 14q24.3. The NPC2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, and frog.240 organisms have orthologs with human gene NPC2.