NEDD4 Information: NEDD4 Protein, NEDD4 Antibody and NEDD4 Gene

NEDD4 Protein

NEDD4 protein function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).

NEDD4 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

NEDD4 Antibody

There are 1 NEDD4 antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 1 NEDD4 antibody for IHC-P. Among all these NEDD4 antibodies, there are 1 anti-NEDD4 rabbit polyclonal antibodies . All the NEDD4 anbodies are produced in house and all are in stock. NEDD4 antibody customerized service is available.

NEDD4 Gene

NEDD4 cDNA / gene is a gene with protein product which located on 15q21.3. The NEDD4 gene is conserved in Rhesus monkey, dog, cow, chicken, and frog. 230 organisms have orthologs with human gene NEDD4.