MOG gene / cDNA is a protein-coding gene which located on 6p22.1. The MOG gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.119 organisms have orthologs with human gene MOG.
Myelin Oligodendrocyte Glycoprotein cDNA / Gene Function
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]