MST1 Protein Overview: Sequence, Structure, Function and Protein Interaction

MST1 Protein Overview

MST1 protein family

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

MST1 protein name

Recommended name
Serine/threonine-protein kinase 4
Aliases
kinase responsive to stress 2, KRS2, mammalian sterile 20-like 1, MST1, yeast Ste20-like, YSK3
Alternative name
Mammalian STE20-like protein kinase 1 STE20-like kinase MST1 Serine/threonine-protein kinase Krs-2 Serine/threonine-protein kinase 4 37kDa subunit Serine/threonine-protein kinase 4 18kDa subunit

MST1 Protein Sequence

Species Human MST1 protein
Length 487
Mass (Da) 55630
Sequence Human MST1 protein sequence
Species Mouse MST1 protein
Length 487
Mass (Da) 55541
Sequence Mouse MST1 protein sequence
Species
Length
Mass (Da)
Sequence

MST1 Protein Molecular Weight & PI

Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Contains: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-487 Serine/threonine-protein kinase 4.

Molecular weight (Da)

55630.16

Theoretical pI

4.97

MST1 Protein Structure

Crystal structure of STK4 (MST1) SARAH domain
Deposited
2013-11-26   Released:  2014-01-29
Deposition Author(s)
Chaikuad, A., Krojer, T., Kopec, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Organism(s)
Homo sapiens
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.0000 Å
R-Value Free
0.240
R-Value Work
0.207
4NR2 From PDB

Human MST1 protein Secondary structure

MST1 Protein Interaction

Recombinant MST1 Protein Feature

MST1 Protein, Human, Recombinant (His Tag)

High Purity
> 92 % as determined by SDS-PAGE.
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
The specific activity was determined to be >150 nmol/min/mg using MBP as substrate.

Recombinant MST1 protein citations

Title
Method for Diagnosing or Determining the Prognosis of Colorectal Cancer (CRC) Using Novel Autoantigens: Gene Expression Guided Autoantigen Discovery
Year
2012
Author
MJ Lim, C Sears, KJ Rothschild
Journal
US 20130040839 A1

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