MST1 Gene Sequence, Family, Fuction and Expression Information

MST1 cDNA / Gene Overview

STK4 gene / cDNA is a protein-coding gene which located on 20q13.12. The STK4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.198 organisms have orthologs with human gene STK4.

MST1 cDNA / Gene Function

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

MST1 cDNA / Gene Sequence

LOCUS
LOCUS NM_006282 6382 bp mRNA linear PRI 03-JUN-2018
DEFINITION
Homo sapiens serine/threonine kinase 4 (STK4), transcript variant 1, mRNA.
ACCESSION
NM_006282
VERSION
NM_006282.4

This sequence information is just for reference only.

MST1 cDNA / Gene Alias

  • kinase responsive to stress 2
  • KRS2
  • mammalian sterile 20-like 1
  • MST1
  • yeast Ste20-like
  • YSK3

MST1 cDNA / Gene Expression

Broad expression in lymph node (RPKM 17.1), appendix (RPKM 14.6) and 24 other tissues