MST1 Information: MST1 Protein, MST1 Antibody and MST1 Gene

MST1 Protein

MST1 protein function

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}.

MST1 protein expression

Tissue specificity

Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Ubiquitously expressed.

Induction

Activity increases during mitosis.

MST1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    487.00
  • Mass (KDa)
    55.00

MST1 Antibody

There are 8 MST1 antibodies which are validated in multiple tissues with various applications, including FCM, ICC/IF, ELISA, ELISA(Det), ELISA(Cap), IHC-P, WB, IP. There are 1 MST1 antibody for FCM, 1 MST1 antibody for ICC/IF, 4 MST1 antibody for ELISA, 1 MST1 antibody for ELISA(Det), 1 MST1 antibody for ELISA(Cap), 2 MST1 antibody for IHC-P, 1 MST1 antibody for WB, 1 MST1 antibody for IP. Among all these MST1 antibodies, there are 4 anti-MST1 mouse monoclonal antibodies , 2 anti-MST1 rabbit monoclonal antibodies , 2 anti-MST1 rabbit polyclonal antibodies . All the MST1 anbodies are produced in house and all are in stock. MST1 antibody customerized service is available.

MST1 Gene

STK4 gene / cDNA is a protein-coding gene which located on 20q13.12. The STK4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.198 organisms have orthologs with human gene STK4.