MS4A2 Gene Sequence, Family, Fuction and Expression Information

MS4A2 cDNA / Gene Overview

MS4A2 cDNA / gene is a gene with protein product which located on 11q12.1. The MS4A2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. 105 organisms have orthologs with human gene MS4A2.

MS4A2 cDNA / Gene Function

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]

MS4A2 cDNA / Gene Sequence

LOCUS
HUMRIGBCHA 11298 bp DNA linear PRI 09-JAN-1995
DEFINITION
Human high affinity IgE receptor beta chain gene, complete cds.
ACCESSION
M89796
VERSION
M89796.1

This sequence information is just for reference only.

MS4A2 Family & Reagents

MS4A2 Gene family reagents (Membrane spanning 4-domains)

Approved Symbol Reagent list
MS4A1

MS4A2 cDNA / Gene Alias

  • Fc fragment of IgE
  • high affinity I
  • receptor for; beta polypeptide
  • MS4A1

MS4A2 cDNA / Gene Expression

Biased expression in lung (RPKM 8.1), gall bladder (RPKM 5.4) and 13 other tissues