MMP7 Gene Sequence, Family, Fuction and Expression Information
MMP7 cDNA / Gene Overview
MMP7 gene / cDNA is a protein-coding gene which located on 11q22.2. The MMP7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, A.thaliana, and rice.172 organisms have orthologs with human gene MMP7.
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]
MMP7 cDNA / Gene Sequence
LOCUS NM_002423 1153 bp mRNA linear PRI 05-AUG-2018
Homo sapiens matrix metallopeptidase 7 (MMP7), mRNA.
This sequence information is just for reference only.