MMP7 Gene Sequence, Family, Fuction and Expression Information

MMP7 cDNA / Gene Overview

MMP7 gene / cDNA is a protein-coding gene which located on 11q22.2. The MMP7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, A.thaliana, and rice.172 organisms have orthologs with human gene MMP7.

MMP7 cDNA / Gene Function

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]

MMP7 cDNA / Gene Sequence

LOCUS
LOCUS NM_002423 1153 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens matrix metallopeptidase 7 (MMP7), mRNA.
ACCESSION
NM_002423
VERSION
NM_002423.4

This sequence information is just for reference only.

MMP7 Family & Reagents

MMP7 Gene family reagents (M10 matrix metallopeptidases)

Approved Symbol Reagent list
MMP1
MMP19
MMP26
MMP8
Approved Symbol Reagent list
MMP12
MMP2
MMP3
MMP9

MMP7 cDNA / Gene Alias

  • matrilysin
  • PUMP-1

MMP7 cDNA / Gene Expression

Biased expression in gall bladder (RPKM 292.4), endometrium (RPKM 62.1) and 3 other tissues