Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721).
MMP21 protein expression
Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
MMP21 cDNA / gene is a gene with protein product which located on 10q26.2. The MMP21 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, zebrafish, and frog. 142 organisms have orthologs with human gene MMP21.