MMP-3 Gene Sequence, Family, Fuction and Expression Information

MMP-3 cDNA / Gene Overview

MMP3 gene / cDNA is a protein-coding gene which located on 11q22.2. The MMP3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.44 organisms have orthologs with human gene MMP3.

MMP-3 cDNA / Gene Function

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

MMP-3 cDNA / Gene Sequence

LOCUS
LOCUS NM_002422 1906 bp mRNA linear PRI 12-AUG-2018
DEFINITION
Homo sapiens matrix metallopeptidase 3 (MMP3), mRNA.
ACCESSION
NM_002422
VERSION
NM_002422.4

This sequence information is just for reference only.

MMP-3 Family & Reagents

MMP-3 Gene family reagents (M10 matrix metallopeptidases)

Approved Symbol Reagent list
MMP1
MMP19
MMP26
MMP8
Approved Symbol Reagent list
MMP12
MMP2
MMP7
MMP9

MMP-3 cDNA / Gene Expression

Biased expression in endometrium (RPKM 37.5), appendix (RPKM 12.3) and 1 other tissue