MMP-3 Gene Sequence, Family, Fuction and Expression Information
MMP-3 cDNA / Gene Overview
MMP3 gene / cDNA is a protein-coding gene which located on 11q22.2. The MMP3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.44 organisms have orthologs with human gene MMP3.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
MMP-3 cDNA / Gene Sequence
LOCUS NM_002422 1906 bp mRNA linear PRI 12-AUG-2018
Homo sapiens matrix metallopeptidase 3 (MMP3), mRNA.
This sequence information is just for reference only.