MMP-2 Gene Sequence, Family, Fuction and Expression Information

MMP-2 cDNA / Gene Overview

MMP2 gene / cDNA is a protein-coding gene which located on 16q12.2. The MMP2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.231 organisms have orthologs with human gene MMP2.

MMP-2 cDNA / Gene Function

This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

MMP-2 cDNA / Gene Sequence

LOCUS
LOCUS NM_001127891 3416 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens matrix metallopeptidase 2 (MMP2), transcript variant 2, mRNA.
ACCESSION
NM_001127891
VERSION
NM_001127891.2

This sequence information is just for reference only.

MMP-2 Family & Reagents

MMP-2 Gene family reagents (M10 matrix metallopeptidases)

Approved Symbol Reagent list
MMP1
MMP19
MMP3
MMP8
Approved Symbol Reagent list
MMP12
MMP26
MMP7
MMP9

MMP-2 cDNA / Gene Alias

  • TBE-1

MMP-2 cDNA / Gene Expression

Broad expression in gall bladder (RPKM 482.6), urinary bladder (RPKM 341.0) and 15 other tissues

Recombinant MMP-2 protein citations

Title
Cordyceps sinensis polysaccharide CPS-2 protects human mesangial cells from PDGF-BB-induced proliferation through the PDGF/ERK and TGF-β1/Smad pathways
Year
2014
Author
Wang, Y;Liu, D;Zhao, H;Jiang, H;Luo, C;Wang, M;Yin, H;
Journal
Mol. Cell. Endocrinol.
Title
miR-19b 在骨肉瘤组织中的表达及其通过调控 KLF13 影响骨肉瘤 Saos-2 细胞侵袭和迁移的研究
Year
2019
Author
钱万锋, ;王秀峰, ;陈学鹏, ;
Journal
中国临床药理学与治疗学