MBP/Myelin Basic Protein Information: MBP/Myelin Basic Protein Protein, MBP/Myelin Basic Protein Antibody and MBP/Myelin Basic Protein Gene

MBP/Myelin Basic Protein Protein

MBP/Myelin Basic Protein protein function

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

MBP/Myelin Basic Protein protein expression

Tissue specificity

MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.

Induction

Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16 weeks and its relative proportion declines thereafter.

MBP/Myelin Basic Protein protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    304.00
  • Mass (Da)
    33.00

MBP/Myelin Basic Protein Gene

MBP cDNA / gene is a gene with protein product which located on 18q23. The MBP gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, and frog. 224 organisms have orthologs with human gene MBP.