MASP2 Gene Sequence, Family, Fuction and Expression Information
MASP2 cDNA / Gene Overview
MASP2 gene / cDNA is a protein-coding gene which located on 1p36.22. The MASP2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.224 organisms have orthologs with human gene MASP2.
This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
MASP2 cDNA / Gene Sequence
LOCUS NM_006610 2471 bp mRNA linear PRI 25-JUN-2018