MASP2 Gene Sequence, Family, Fuction and Expression Information

MASP2 cDNA / Gene Overview

MASP2 gene / cDNA is a protein-coding gene which located on 1p36.22. The MASP2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.224 organisms have orthologs with human gene MASP2.

MASP2 cDNA / Gene Function

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

MASP2 cDNA / Gene Sequence

LOCUS
LOCUS NM_006610 2471 bp mRNA linear PRI 25-JUN-2018
DEFINITION
Homo sapiens mannan binding lectin serine peptidase 2 (MASP2), transcript variant 1, mRNA.
ACCESSION
NM_006610
VERSION
NM_006610.3

This sequence information is just for reference only.

MASP2 Family & Reagents

MASP2 Gene family reagents (Sushi domain containing)

Approved Symbol Reagent list
C7
CD55
SELP
C6
APOH
F13B
SELE
IL15RA
CR2
CFB
Approved Symbol Reagent list
CD46
CFHR2
SEZ6L2
C2
HP
SELL
SUSD4
PAPPA2
CFHR1
CFH

MASP2 cDNA / Gene Expression

Biased expression in liver (RPKM 26.8), bone marrow (RPKM 2.7) and 7 other tissues