LFA-1 Gene Sequence, Family, Fuction and Expression Information

LFA-1 cDNA / Gene Overview

ITGAL gene / cDNA is a protein-coding gene which located on 16p11.2. The ITGAL gene is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish.126 organisms have orthologs with human gene ITGAL.

LFA-1 cDNA / Gene Function

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LFA-1 cDNA / Gene Sequence

LOCUS
LOCUS NM_001114380 4974 bp mRNA linear PRI 24-JUN-2018
DEFINITION
Homo sapiens integrin subunit alpha L (ITGAL), transcript variant 2, mRNA.
ACCESSION
NM_001114380
VERSION
NM_001114380.1

This sequence information is just for reference only.

LFA-1 Family & Reagents

Gene family

LFA-1 Gene family reagents (CD molecules)

Approved Symbol Reagent list
BMPR1A
SIRPG
IL2RG
CD36
TNFRSF21
CD1B
LILRA4
DDR1
CD160
IL5RA
Approved Symbol Reagent list
TNFRSF12A
TNFRSF14
ICAM4
FCAR
IL4R
IL12RB1
CD82
CD58
TNFRSF10D
LILRB4

LFA-1 cDNA / Gene Alias

  • antigen CD11A (p180)
  • LFA-1
  • lymphocyte function-associated antigen 1
  • alpha polypeptide

LFA-1 cDNA / Gene Expression

Biased expression in lymph node (RPKM 36.8), spleen (RPKM 35.7) and 11 other tissues