LFA-1 Gene Sequence, Family, Fuction and Expression Information
LFA-1 cDNA / Gene Overview
ITGAL gene / cDNA is a protein-coding gene which located on 16p11.2. The ITGAL gene is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish.126 organisms have orthologs with human gene ITGAL.
LFA-1 cDNA / Gene Function
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
LFA-1 cDNA / Gene Sequence
LOCUS
LOCUS NM_001114380 4974 bp mRNA linear PRI 24-JUN-2018
DEFINITION
Homo sapiens integrin subunit alpha L (ITGAL), transcript variant 2, mRNA.
ACCESSION
NM_001114380
VERSION
NM_001114380.1
This sequence information is just for reference only.
LFA-1 Family & Reagents
Gene family
LFA-1 Gene family reagents (CD molecules)
LFA-1 cDNA / Gene Alias
- antigen CD11A (p180)
- LFA-1
- lymphocyte function-associated antigen 1
- alpha polypeptide
LFA-1 cDNA / Gene Expression
Biased expression in lymph node (RPKM 36.8), spleen (RPKM 35.7) and 11 other tissues
