Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
LAT2/NTAL protein expression
Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
LAT2 cDNA / gene is a gene with protein product which located on 7q11.23. The LAT2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. 157 organisms have orthologs with human gene LAT2.