LAT Gene Sequence, Family, Fuction and Expression Information
LAT cDNA / Gene Overview
LAT cDNA / gene is a gene with protein product which located on 16q13. The LAT gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. 123 organisms have orthologs with human gene LAT.
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
LAT cDNA / Gene Sequence
AF036905 1060 bp mRNA linear PRI 06-MAR-1998
Homo sapiens linker for activation of T cells (LAT) mRNA, complete cds.
This sequence information is just for reference only.
LAT cDNA / Gene Alias
linker for activation of T cells
LAT cDNA / Gene Expression
Broad expression in lymph node (RPKM 29.3), appendix (RPKM 13.0) and 19 other tissues