LAT Information: LAT Protein, LAT Antibody and LAT Gene

LAT Protein

LAT protein function

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

LAT protein expression

Tissue specificity

Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).

LAT protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    262.00
  • Mass (KDa)
    27.00

LAT Gene

LAT cDNA / gene is a gene with protein product which located on 16q13. The LAT gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. 123 organisms have orthologs with human gene LAT.