IL9R Protein Overview: Sequence, Structure, Function and Protein Interaction

IL9R Protein Overview

Russell et al. (1993) suggested that the interleukin receptor common gamma chain, or gamma-c (IL2RG; 308380), may be shared with the IL9 receptor. Demoulin et al. (1996) expressed mutated IL9R molecules and showed that a single tyrosine at position 116 in the receptor's intracellular domain is phosphorylated after IL9 binding and mediates the activation of STAT1, STAT3 (102582), and STAT5 (601511). They also showed that JAK1 is constitutively associated with IL9R and that activation of JAK1 depends on a distinct intracellular domain of IL9R. Ihle and Kerr (1995) reviewed the activation cascade involving cytokines, cytokine receptors, the Janus kinases (see JAK1; 147795), and the signal transducers and activators of transcription, or STATs (see STAT1; 600555). IL9R is expressed on many hemopoietic cells, including T cells, mast cells, and macrophages. By RT-PCR analysis, Abdelilah et al. (2001) detected expression of IL9R in polymorphonuclear neutrophils (PMNs) from all asthmatic patients tested but in only some controls. Flow cytometric analysis demonstrated surface expression of IL9R on PMNs of all asthmatics tested, with less intense expression on neutrophils of some controls. Immunohistochemical analysis revealed surface and intracytoplasmic expression in all asthmatic PMNs and bronchoalveolar lavage cells, but little or no expression in control PMNs. Functional analysis showed that recombinant IL9 could induce PMNs from asthmatic patients to produce IL8 (146930), a proinflammatory cytokine, at higher levels than from control PMNs. Using flow cytometry and RT-PCR analysis, Gounni et al. (2004) found that human airway smooth muscle (ASM) cells expressed IL9R mRNA constitutively and IL9R protein on their surface. Incubation of ASM cells with IL9 induced dose-dependent, IL13 (147683)- and IL4 (147780)-independent secretion of CCL11 (601156), which in turn recruited eosinophils. IL9 had no effect on the release of CCL17 (601520). Gounni et al. (2004) concluded that IL9-dependent activation of ASM cells via IL9R contributes to eosinophilic inflammation observed in asthma.

IL9R protein family

Belongs to the type I cytokine receptor family. Type 4 subfamily.

IL9R protein name

Recommended name
Interleukin-9 receptor
Short name
IL-9 receptor||IL-9R
Aliases
CD129
Alternative name
CD_antigen: CD129

IL9R Gene family protein

IL9R Protein Sequence

Species Human IL9R protein
Length 521
Mass (Da) 57147
Sequence Human IL9R protein sequence
Species Mouse IL9R protein
Length 468
Mass (Da) 52261
Sequence Mouse IL9R protein sequence
Species
Length
Mass (Da)
Sequence

IL9R Protein Molecular Weight & PI

Interleukin-9 receptor precursor (IL-9 receptor) (IL-9R) (CD129 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 41-521 Interleukin-9 receptor.

Molecular weight (Da)

52701.49

Theoretical pI

5.30

IL9R Protein Interaction

Recombinant IL9R Protein Feature

IL9R Protein, Rat, Recombinant (His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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