IL21 Gene Sequence, Family, Fuction and Expression Information

IL21 cDNA / Gene Overview

IL21 gene / cDNA is a protein-coding gene which located on 4q27. The IL21 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.157 organisms have orthologs with human gene IL21.

IL21 cDNA / Gene Function

This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

IL21 cDNA / Gene Sequence

LOCUS
LOCUS NM_021803 3146 bp mRNA linear PRI 31-JUL-2018
DEFINITION
Homo sapiens interleukin 21 (IL21), transcript variant 1, mRNA.
ACCESSION
NM_021803
VERSION
NM_021803.4

This sequence information is just for reference only.

IL21 Family & Reagents

Gene family

IL21 Gene family reagents (Interleukins)

Approved Symbol Reagent list
IL1RN
IL10
IL37
IL25
IL19
IL20
IL17B
IL12B
IL36G
IL27
Approved Symbol Reagent list
CXCL8
IL5
IL17F
IL36RN
IL23A
IL2
IL34
IL6
IL36A
IL1F10

IL21 cDNA / Gene Alias

  • IL-21
  • Za11

IL21 cDNA / Gene Expression

Biased expression in lymph node (RPKM 3.2), testis (RPKM 0.8) and 2 other tissues