IL17RD Information: IL17RD Protein, IL17RD Antibody and IL17RD Gene

IL17RD Gene family

IL17RD Protein

IL17RD protein function

Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). {ECO:0000250, ECO:0000269|PubMed:12807873, ECO:0000269|PubMed:12958313, ECO:0000269|PubMed:15239952}.

IL17RD protein expression

Tissue specificity

Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituitary, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary. Isoform 1 is also expressed at moderate levels in primary aortic endothelial cells and adrenal medulla, and at low levels in adrenal cortex. Isoform 4 is specifically and highly expressed in pituitary, fetal brain and umbilical vein endothelial cells.

IL17RD protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    739.00
  • Mass (KDa)
    82.00

IL17RD Antibody

There are 5 IL17RD antibodies which are validated in multiple tissues with various applications, including ELISA(Cap), ELISA. There are 1 IL17RD antibody for ELISA(Cap), 4 IL17RD antibody for ELISA. Among all these IL17RD antibodies, there are 2 anti-IL17RD rabbit monoclonal antibodies , 3 anti-IL17RD rabbit polyclonal antibodies . All the IL17RD anbodies are produced in house and all are in stock. IL17RD antibody customerized service is available.

IL17RD Gene

IL17RD gene / cDNA is a protein-coding gene which located on 3p14.3. The IL17RD gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.242 organisms have orthologs with human gene IL17RD.