IL-12 p70/IL12A Protein Overview: Sequence, Structure, Function and Protein Interaction

IL-12 p70/IL12A Protein Overview

IL-12 p70/IL12A reagents

IL12A, or p35, is a subunit in 2 distinct heterodimeric cytokines: interleukin-12 (IL12) and IL35. IL12 is composed of 40-kD (p40, or IL12B; 161561) and 35-kD (p35) subunits and functions to activate and link the innate and acquired immune responses (Wolf et al., 1994). IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of Epstein-Barr virus (EBV)-induced gene-3 (EBI3; 605816) and the ubiquitously expressed p35 subunit of IL12 (Niedbala et al., 2007; Collison et al., 2007).

IL-12 p70/IL12A protein family

Belongs to the IL-6 superfamily.

IL-12 p70/IL12A protein name

Recommended name
Interleukin-12 subunit alpha
Short name
IL-12A||CLMF p35||NKSF1
CLMF, cytotoxic lymphocyte maturation factor 1, p35, IL-12, subunit p35, IL-12A, IL35 subunit, interleukin 12, p35, interleukin-12 alpha chain, natural killer cell stimulatory factor 1, 35 kD subunit, NF cell stimulatory factor chain 1, NFSK, p35
Alternative name
Cytotoxic lymphocyte maturation factor 35 kDa subunit IL-12 subunit p35 NK cell stimulatory factor chain 1

IL-12 p70/IL12A Protein Sequence

Species Human IL-12 p70/IL12A protein
Length 219
Mass (Da) 24874
Sequence Human IL-12 p70/IL12A protein sequence
Species Mouse IL-12 p70/IL12A protein
Length 215
Mass (Da) 24179
Sequence Mouse IL-12 p70/IL12A protein sequence
Species Rat IL-12 p70/IL12A protein
Length 215
Mass (Da) 24246
Sequence Rat IL-12 p70/IL12A protein sequence

IL-12 p70/IL12A Protein Molecular Weight & PI

Interleukin-12 subunit alpha precursor (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35) (NK cell stimulatory factor chain 1) (NKSF1) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 23-219 Interleukin-12 subunit alpha.

Molecular weight (Da)


Theoretical pI


IL-12 p70/IL12A Protein Structure

2000-06-07   Released:  2001-06-20
Deposition Author(s)
Yoon, C., Johnston, S.C., Tang, J., Tobin, J.F., Somers, W.S.
Homo sapiens
Expression System
Cricetulus griseus
Experimental Data Snapshot
2.8000 Å
R-Value Free
R-Value Work
1F45 From PDB

Human IL-12 p70/IL12A protein Secondary structure

IL-12 p70/IL12A Protein Interaction

Recombinant IL-12 p70/IL12A Protein Feature

IL-12 p70/IL12A Protein, Human, Recombinant (hFc Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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