IGF1R Protein Overview: Sequence, Structure, Function and Protein Interaction

IGF1R Protein Overview

IGF1R reagents

Crystal StructureLou et al. (2006) reported the crystal structure of the first 3 domains of INSR at 2.3-angstrom resolution and compared it with the structure of the corresponding fragment of IGF1R. They observed notable differences in the regions governing ligand specificity and binding.

IGF1R protein family

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

IGF1R protein name

Recommended name
Insulin-like growth factor 1 receptor
Short name
IGF-I receptor
CD221, IGFIR, IGFR, JTK13, MGC18216
Alternative name
Insulin-like growth factor I receptor CD_antigen: CD221 Insulin-like growth factor 1 receptor alpha chain Insulin-like growth factor 1 receptor beta chain

IGF1R Gene family protein

IGF1R Protein Sequence

Species Human IGF1R protein
Length 1367
Mass (Da) 154793
Sequence Human IGF1R protein sequence
Species Mouse IGF1R protein
Length 1373
Mass (Da) 155788
Sequence Mouse IGF1R protein sequence
Species Rat IGF1R protein
Length 1370
Mass (Da) 155396
Sequence Rat IGF1R protein sequence

IGF1R Protein Molecular Weight & PI

Insulin-like growth factor 1 receptor precursor (EC (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 31-736 Insulin-like growth factor 1 receptor

Molecular weight (Da)


Theoretical pI


IGF1R Protein Structure

Structure of NVP-AEW541 in complex with IGF-1R kinase
2016-02-02   Released:  2016-04-06
Deposition Author(s)
Cowan-Jacob, S.W.
Homo sapiens
Expression System
unidentified baculovirus
Experimental Data Snapshot
2.2000 Å
R-Value Free
R-Value Work

Human IGF1R protein Secondary structure

IGF1R Protein Interaction

Recombinant IGF1R Protein Feature

IGF1R Protein, Human, Recombinant (His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
1. Measured by its ability to bind biotinylated human IGF1 in a functional ELISA. 2. Using the Octet RED System, the affinity constant (Kd) of IGF1R Protein, Human, Recombinant (His Tag) (Cat.10164-H08H) bound to Human IGF-1 Protein was 0.08 μM.

Recombinant IGF1R protein citations

Cytotoxic trichothecene-type sesquiterpenes from the sponge-derived fungus Stachybotrys chartarum with tyrosine kinase inhibition
Li, Y;Liu, D;Cheng, Z;Proksch, P;Lin, W;
RSC Advances

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