HMGB1 Gene Sequence, Family, Fuction and Expression Information
HMGB1 cDNA / Gene Overview
HMGB1 gene / cDNA is a protein-coding gene which located on 13q12.3. The HMGB1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.202 organisms have orthologs with human gene HMGB1.
This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]
HMGB1 cDNA / Gene Sequence
LOCUS NM_002128 4285 bp mRNA linear PRI 15-JUL-2018
Homo sapiens high mobility group box 1 (HMGB1), transcript variant 2, mRNA.
This sequence information is just for reference only.