HMGB1 Gene Sequence, Family, Fuction and Expression Information

HMGB1 cDNA / Gene Overview

HMGB1 gene / cDNA is a protein-coding gene which located on 13q12.3. The HMGB1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.202 organisms have orthologs with human gene HMGB1.

HMGB1 cDNA / Gene Function

This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

HMGB1 cDNA / Gene Sequence

LOCUS
LOCUS NM_002128 4285 bp mRNA linear PRI 15-JUL-2018
DEFINITION
Homo sapiens high mobility group box 1 (HMGB1), transcript variant 2, mRNA.
ACCESSION
NM_002128
VERSION
NM_002128.6

This sequence information is just for reference only.

HMGB1 Family & Reagents

HMGB1 Gene family reagents (Canonical high mobility group)

Approved Symbol Reagent list
HMGN3

HMGB1 cDNA / Gene Alias

  • Amphoterin
  • DKFZp686A04236
  • high mobility group box 1
  • high mobility group protein 1
  • HMG3
  • SBP-1
  • Sulfoglucuronyl carbohydrate binding protein

HMGB1 cDNA / Gene Expression

Ubiquitous expression in bone marrow (RPKM 98.7), lymph node (RPKM 87.4) and 25 other tissues

Recombinant HMGB1 protein citations

Title
Ulinastatin Preconditioning Attenuates Inflammatory Reaction of Hepatic Ischemia Reperfusion Injury in Rats via High Mobility Group Box 1 (HMGB1) …
Year
2014
Author
Y Tong, Z Tang, T Yang, Y Yang, L Yang…
Journal
International Journal of Medic al Sc iences