GSK3B Gene Sequence, Family, Fuction and Expression Information

GSK3B cDNA / Gene Overview

GSK3B gene / cDNA is a protein-coding gene which located on 3q13.33. The GSK3B gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, A.thaliana, rice, and frog.222 organisms have orthologs with human gene GSK3B.

GSK3B cDNA / Gene Function

The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]

GSK3B cDNA / Gene Sequence

LOCUS
LOCUS NM_001146156 7095 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens glycogen synthase kinase 3 beta (GSK3B), transcript variant 2, mRNA.
ACCESSION
NM_001146156
VERSION
NM_001146156.1

This sequence information is just for reference only.

GSK3B cDNA / Gene Expression

Ubiquitous expression in brain (RPKM 13.9), thyroid (RPKM 9.9) and 25 other tissues