Gremlin 1/GREM1 Information: Gremlin 1/GREM1 Protein, Gremlin 1/GREM1 Antibody and Gremlin 1/GREM1 Gene

Gremlin 1/GREM1 Gene family

Gremlin 1/GREM1 Protein

Gremlin 1/GREM1 protein function

Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). {ECO:0000250|UniProtKB:O35793, ECO:0000250|UniProtKB:O70326, ECO:0000269|PubMed:27036124}.

Gremlin 1/GREM1 protein expression

Tissue specificity

Highly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very high levels in epithelial cells (predominantly colonocytes), with expression extending most of the way up the sides of the crypt. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts.

Induction

By high glucose through TGFB1-mediated pathways in mesangial cell. Down-regulated in tumor cell lines.

Gremlin 1/GREM1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    184.00
  • Mass (KDa)
    20.00

Gremlin 1/GREM1 Antibody

There are 2 Gremlin 1/GREM1 antibodies which are validated in multiple tissues with various applications, including ELISA, WB, IHC-P. There are 1 Gremlin 1/GREM1 antibody for ELISA, 1 Gremlin 1/GREM1 antibody for WB, 1 Gremlin 1/GREM1 antibody for IHC-P. Among all these Gremlin 1/GREM1 antibodies, there are 1 anti-Gremlin 1/GREM1 rabbit monoclonal antibodies , 1 anti-Gremlin 1/GREM1 rabbit polyclonal antibodies . All the Gremlin 1/GREM1 anbodies are produced in house and all are in stock. Gremlin 1/GREM1 antibody customerized service is available.

Gremlin 1/GREM1 Gene

GREM1 gene / cDNA is a protein-coding gene which located on 15q13.3. The GREM1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, and frog.226 organisms have orthologs with human gene GREM1.