GAPDH Information: GAPDH Protein, GAPDH Antibody and GAPDH Gene

GAPDH Protein

GAPDH protein function

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. {ECO:0000250, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:3170585}.

GAPDH protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    335.00
  • Mass (KDa)
    36.00

GAPDH Antibody

There are 8 GAPDH antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, ELISA, IP. There are 5 GAPDH antibody for WB, 3 GAPDH antibody for IHC-P, 2 GAPDH antibody for ELISA, 1 GAPDH antibody for IP. Among all these GAPDH antibodies, there are 3 anti-GAPDH mouse monoclonal antibodies , 2 anti-GAPDH rabbit monoclonal antibodies , 3 anti-GAPDH rabbit polyclonal antibodies . All the GAPDH anbodies are produced in house and all are in stock. GAPDH antibody customerized service is available.

GAPDH Gene

GAPDH gene / cDNA is a protein-coding gene which located on 12p13.31. The GAPDH gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, S.pombe, M.oryzae, N.crassa, rice, and frog.232 organisms have orthologs with human gene GAPDH.