FLT1 cDNA Clone: Expression and Clone Vector / Plasmid

FLT1 cDNA / Gene Overview

FLT1 gene / cDNA is a protein-coding gene which located on 13q12.3. The FLT1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, and zebrafish.213 organisms have orthologs with human gene FLT1.

FLT1 cDNA / Gene Function

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

FLT1 cDNA / Gene Sequence

LOCUS
LOCUS NM_002019 7123 bp mRNA linear PRI 01-JUL-2018
DEFINITION
Homo sapiens fms related tyrosine kinase 1 (FLT1), transcript variant 1, mRNA.
ACCESSION
NM_002019
VERSION
NM_002019.4

This sequence information is just for reference only.

FLT1 Family & Reagents

FLT1 Gene family reagents (Receptor Tyrosine Kinases)

Approved Symbol Reagent list
RYK
FGFR1
FLT3
MST1R
FGFR3
PDGFRB
AXL
NTRK2
FGFR2
ROR1
Approved Symbol Reagent list
MET
ROR2
TEK
MERTK
FLT4
RET
FGFR4
MUSK
DDR2
CSF1R

FLT1 Gene family reagents (I-set domain containing)

Approved Symbol Reagent list
TMIGD1
NCAM2
JAM2
FGFR3
ROBO4
CNTN2
FGFR4
FGFR2
CLMP
MFAP3
Approved Symbol Reagent list
WFIKKN2
LRRN3
MDGA2
CEACAM5
IL1RL1
KDR
MUSK
NTM
LSAMP
CNTN3

FLT1 Gene family reagents (Immunoglobulin like domain containing)

Approved Symbol Reagent list
IL18R1
IL1RAPL1
NECTIN3
MILR1
JAM3
CLMP
KIRREL3
CD47
NTRK1
ICAM5
Approved Symbol Reagent list
SEMA3A
FCGR3A
CXADR
MUSK
NCR1
NECTIN1
FCAR
AXL
KIRREL2
CHL1

FLT1 cDNA / Gene Alias

  • vascular endothelial growth factor receptor 1
  • vascular permeability factor receptor
  • VEGFR1

FLT1 cDNA / Gene Expression

Biased expression in placenta (RPKM 90.6), thyroid (RPKM 20.1) and 8 other tissues