Fibronectin Gene Sequence, Family, Fuction and Expression Information

Fibronectin cDNA / Gene Overview

FN1 gene / cDNA is a protein-coding gene which located on 2q35. The FN1 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, and frog.207 organisms have orthologs with human gene FN1.

Fibronectin cDNA / Gene Function

This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]

Fibronectin cDNA / Gene Sequence

LOCUS
LOCUS NM_212476 8290 bp mRNA linear PRI 03-JUN-2018
DEFINITION
Homo sapiens fibronectin 1 (FN1), transcript variant 5, mRNA.
ACCESSION
NM_212476
VERSION
NM_212476.2

This sequence information is just for reference only.

Fibronectin Family & Reagents

Fibronectin Gene family reagents (Endogenous ligands)

Approved Symbol Reagent list
CALCB
CCL13
RLN1
TGFB1
MLN
PPBP
FASLG
FLT3LG
LGALS3
LIF
Approved Symbol Reagent list
CXCL16
FSHB
INS
FGF7
CXCL1
IGF1
NTS
FGF1
CCL1
BMP2

Fibronectin Gene family reagents (Fibronectin type III domain containing)

Approved Symbol Reagent list
EphA2
EphA7
EphA4
EphA6
L1CAM
ROBO4
AXL
ROBO2
OSMR
EPOR
Approved Symbol Reagent list
NFASC
LRRN3
CNTN5
IFNGR2
CNTN6
FLRT1
EphB4
IL31RA
INSR
CDON

Fibronectin cDNA / Gene Alias

  • CIG
  • cold-insoluble globulin
  • FINC
  • GFND2
  • LETS
  • migration-stimulating factor
  • MSF

Fibronectin cDNA / Gene Expression

Biased expression in placenta (RPKM 1097.5), liver (RPKM 415.5) and 7 other tissues