FCER1G Information: FCER1G Protein, FCER1G Antibody and FCER1G Gene

FCER1G Protein

FCER1G protein function

Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation.

FCER1G protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    86.00
  • Mass (Da)
    9.00

FCER1G Antibody

There are 1 FCER1G antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 1 FCER1G antibody for IHC-P. Among all these FCER1G antibodies, there are 1 anti-FCER1G rabbit polyclonal antibodies . All the FCER1G anbodies are produced in house and all are in stock. FCER1G antibody customerized service is available.

FCER1G Gene

FCER1G cDNA / gene is a gene with protein product which located on 1q23.3. The FCER1G gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. 161 organisms have orthologs with human gene FCER1G.