EphA3 Information: EphA3 Protein, EphA3 Antibody and EphA3 Gene

EphA3 Gene family

EphA3 Protein

EphA3 protein function

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}.

EphA3 protein expression

Tissue specificity

Widely expressed. Highest level in placenta.

EphA3 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    983.00
  • Mass (Da)
    110.00

EphA3 Antibody

There are 4 EphA3 antibodies which are validated in multiple tissues with various applications, including IHC-P, ELISA. There are 1 EphA3 antibody for IHC-P, 3 EphA3 antibody for ELISA. Among all these EphA3 antibodies, there are 4 anti-EphA3 rabbit polyclonal antibodies . All the EphA3 anbodies are produced in house and all are in stock. EphA3 antibody customerized service is available.

EphA3 Gene

EphA3 gene / cDNA is a protein-coding gene which located on 3p11.1. The EPHA3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.201 organisms have orthologs with human gene EPHA3.