E-Cadherin Gene Sequence, Family, Fuction and Expression Information
E-Cadherin cDNA / Gene Overview
CDH1 gene / cDNA is a protein-coding gene which located on 16q22.1. The CDH1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.136 organisms have orthologs with human gene CDH1.
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
E-Cadherin cDNA / Gene Sequence
LOCUS NM_004360 4845 bp mRNA linear PRI 05-AUG-2018
Homo sapiens cadherin 1 (CDH1), transcript variant 1, mRNA.
This sequence information is just for reference only.