E-Cadherin Gene Sequence, Family, Fuction and Expression Information

E-Cadherin cDNA / Gene Overview

CDH1 gene / cDNA is a protein-coding gene which located on 16q22.1. The CDH1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.136 organisms have orthologs with human gene CDH1.

E-Cadherin cDNA / Gene Function

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

E-Cadherin cDNA / Gene Sequence

LOCUS
LOCUS NM_004360 4845 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens cadherin 1 (CDH1), transcript variant 1, mRNA.
ACCESSION
NM_004360
VERSION
NM_004360.4

This sequence information is just for reference only.

E-Cadherin Family & Reagents

E-Cadherin Gene family reagents (CD molecules)

Approved Symbol Reagent list
CD40LG
IL3Ra
TNFRSF21
FCRL1
ICOS
LIFR
PRNP
KIR2DL3
SIRPG
IL1R2
Approved Symbol Reagent list
CD3D
HAVCR1
BSG
NECTIN1
BCAM
LAMP1
EpCAM
CD40
PTPRJ
FCAMR

E-Cadherin Gene family reagents (Type I classical cadherins)

Approved Symbol Reagent list
CDH15
CDH4
Approved Symbol Reagent list
CDH2
   

E-Cadherin cDNA / Gene Alias

  • CD324
  • E-Cadherin
  • uvomorulin

E-Cadherin cDNA / Gene Expression

Broad expression in thyroid (RPKM 81.8), colon (RPKM 70.0) and 17 other tissues

Recombinant E-Cadherin protein citations

Title
Cellular distribution of the IGF-1R in corneal epithelial cells
Year
2012
Author
Robertson, DM;Zhu, M;Wu, YC;
Journal
Exp. Eye Res.
Title
Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling
Year
2014
Author
Yang, P;Li, Z;Fu, R;Wu, H;Li, Z;
Journal
Cell. Signal.
Title
Polo-like kinase 4 mediates epithelial-mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway
Year
2018
Author
Tian, X;Zhou, D;Chen, L;Tian, Y;Zhong, B;Cao, Y;Dong, Q;Zhou, M;Yan, J;Wang, Y;Qiu, Y;Zhang, L;Li, Z;Wang, H;Wang, D;Ying, G;Zhao, Q;
Journal
Cell Death Dis