DDR2 Protein Overview: Sequence, Structure, Function and Protein Interaction

DDR2 Protein Overview

DDR2 reagents

Using a PCR-mediated approach, Karn et al. (1993) characterized cDNAs from human and mouse representing a novel type of receptor protein tyrosine kinase (RTK). The deduced 855-amino acid sequence of the longest ORF has a unique extracellular region encompassing a factor VIII-like domain, not previously described for RTKs. The most closely related RTKs are members of the neurotrophin receptors (TRKs; see TRKA, 191315), which show 47 to 49% homology with the kinase domain of the novel RTK. Therefore, Karn et al. (1993) called the novel gene TKT (pronounced 'ticket') for 'tyrosine-kinase related to TRK.' TKT orthologs from man and mouse are 98% similar. Northern blot analysis detected a 10-kb transcript that was highly expressed in heart and lung, with lower expression in brain, placenta, liver, skeletal muscle, and kidney. In mouse, highest expression was also detected in heart and lung, with lower expression in brain and testis. Using in situ hybridization with 1-week-old mice, Labrador et al. (2001) found that Ddr2 was expressed along chondrocyte columns in the proliferative region of the growth plate. Ddr2 mRNA was also present, although dispersed, at areas of calcified cartilage in the cartilage-bone junction, as well as in the trabecular bone surface. Ddr2 protein was detected in most mouse tissues examined. Highest levels of phosphorylated Ddr2 were detected in lung, ovary, and skin, which did not correlate with Ddr2 protein levels.

DDR2 protein family

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

DDR2 protein name

Recommended name
Discoidin domain-containing receptor 2
Short name
Discoidin domain receptor 2
Alternative name
CD167 antigen-like family member B Discoidin domain-containing receptor tyrosine kinase 2 Neurotrophic tyrosine kinase, receptor-related 3 Receptor protein-tyrosine kinase TKT Tyrosine-protein kinase TYRO10 CD antigen CD167b

DDR2 Protein Sequence

Species Human DDR2 protein
Length 855
Mass (Da) 96736
Sequence Human DDR2 protein sequence
Species Mouse DDR2 protein
Length 854
Mass (Da) 96482
Sequence Mouse DDR2 protein sequence
Mass (Da)

DDR2 Protein Molecular Weight & PI

Discoidin domain-containing receptor 2 precursor (EC (Discoidin domain receptor 2) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD167b antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 22-855 Discoidin domain-containing receptor 2.

Molecular weight (Da)


Theoretical pI


DDR2 Protein Structure

Crystal structure of the DDR2 discoidin domain bound to a triple- helical collagen peptide
2009-10-05   Released:  2009-12-29
Deposition Author(s)
Carafoli, F., Bihan, D., Stathopoulos, S., Konitsiotis, A.D., Kvansakul, M., Farndale, R.W., Leitinger, B., Hohenester, E.
Homo sapiens
Expression System
Homo sapiens
Experimental Data Snapshot
1.6000 Å
R-Value Free
R-Value Work

Human DDR2 protein Secondary structure

DDR2 Protein Interaction

Recombinant DDR2 Protein Feature

DDR2 Protein, Human, Recombinant (His Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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