CR1/CD35 Gene Sequence, Family, Fuction and Expression Information

CR1/CD35 cDNA / Gene Overview

CR1 gene / cDNA is a protein-coding gene which located on 1q32.2. The CR1 gene is conserved in chimpanzee, Rhesus monkey, and dog.59 organisms have orthologs with human gene CR1.

CR1/CD35 cDNA / Gene Function

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

CR1/CD35 cDNA / Gene Sequence

LOCUS
LOCUS NM_000573 8629 bp mRNA linear PRI 23-JUN-2018
DEFINITION
Homo sapiens complement C3b/C4b receptor 1 (Knops blood group) (CR1), transcript variant F, mRNA.
ACCESSION
NM_000573 XM_936516
VERSION
NM_000573.3

This sequence information is just for reference only.

CR1/CD35 Family & Reagents

CR1/CD35 Gene family reagents (Blood group antigens)

Approved Symbol Reagent list
ABO
ART4
BSG
CD55
CD99
GYPC
XG
Approved Symbol Reagent list
ACHE
BCAM
CD44
CD59
GYPA
ICAM4
   

CR1/CD35 Gene family reagents (CD molecules)

Approved Symbol Reagent list
LILRB1
GP1BB
CD2
PSG1
FCAR
TNFRSF13C
CD177
PTGFRN
PROM1
KIT
Approved Symbol Reagent list
CD276
CLEC10A
CD46
FASLG
CD79B
IL4R
CD44
THY1
CD3E
FCGR1A

CR1/CD35 Gene family reagents (Complement system)

Approved Symbol Reagent list
C1QB
C3
C6
CD46
CFB
CFH
CFHR2
Approved Symbol Reagent list
C2
C5
C7
CD59
CFD
CFHR1
CR2

CR1/CD35 Gene family reagents (Sushi domain containing)

Approved Symbol Reagent list
SELP
F13B
SEZ6L2
IL15RA
CFH
SELE
CFB
IL2RA
SUSD4
C7
Approved Symbol Reagent list
CD55
APOH
CFHR2
TPO
CD46
PAPPA2
C2
HP
CR2
C6

CR1/CD35 cDNA / Gene Alias

  • CD35
  • KN

CR1/CD35 cDNA / Gene Expression

Biased expression in appendix (RPKM 18.3), spleen (RPKM 14.7) and 10 other tissues