COX-2 Protein Overview: Sequence, Structure, Function and Protein Interaction

COX-2 Protein Overview

A major mechanism for the regulation of prostaglandin synthesis occurs at the level of cyclooxygenase, also known as prostaglandin-endoperoxide synthase (PTGS; EC The first rate-limiting step in the conversion of arachidonic acid to prostaglandins is catalyzed by PTGS. Two isoforms of PTGS have been identified: PTGS1 (COX1; 176805) and a mitogen-inducible form, PTGS2. PTGS1 is involved in production of prostaglandins for cellular housekeeping functions, whereas PTGS2 is associated with biologic events such as injury, inflammation, and proliferation (summary by Hla and Neilson (1992) and Tazawa et al. (1994)).

COX-2 protein family

Belongs to the prostaglandin G/H synthase family.

COX-2 protein name

Recommended name
Prostaglandin G/H synthase 2
COX2, cyclooxygenase 2, prostaglandin G / H synthase 2
Alternative name
Cyclooxygenase-2 PHS II Prostaglandin H2 synthase 2 Prostaglandin-endoperoxide synthase 2

COX-2 Protein Sequence

Species Human COX-2 protein
Length 604
Mass (Da) 68996
Sequence Human COX-2 protein sequence
Species Mouse COX-2 protein
Length 604
Mass (Da) 69013
Sequence Mouse COX-2 protein sequence
Species Rat COX-2 protein
Length 604
Mass (Da) 69164
Sequence Rat COX-2 protein sequence

COX-2 Protein Molecular Weight & PI

Prostaglandin G/H synthase 2 precursor (EC (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 18-604 Prostaglandin G/H synthase 2.

Molecular weight (Da)


Theoretical pI


COX-2 Protein Structure

The Crystal Structure of Aspirin Acetylated Human Cyclooxygenase-2
2015-11-30   Released:  2016-03-16
Deposition Author(s)
Lucido, M.J., Orlando, B.J., Malkowski, M.G.
Homo sapiens
Expression System
Spodoptera frugiperda
Experimental Data Snapshot
2.0400 Å
R-Value Free
R-Value Work
5F19 From PDB

Human COX-2 protein Secondary structure

COX-2 Protein Interaction

Recombinant COX-2 Protein Feature

COX-2 Protein, Human, Recombinant (His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant COX-2 protein citations

Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology
Zhang, J;Zhang, Q;Chen, X;Liu, Y;Xue, J;Dahan, A;Zhang, H;Chai, Y;
Evidence-Based Complementary and Alternative Medicine

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