COX-2 Gene Sequence, Family, Fuction and Expression Information

COX-2 cDNA / Gene Overview

PTGS2 gene / cDNA is a protein-coding gene which located on 1q31.1. The PTGS2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.238 organisms have orthologs with human gene PTGS2.

COX-2 cDNA / Gene Function

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]

COX-2 cDNA / Gene Sequence

LOCUS
LOCUS NM_000963 4507 bp mRNA linear PRI 03-JUN-2018
DEFINITION
Homo sapiens prostaglandin-endoperoxide synthase 2 (PTGS2), mRNA.
ACCESSION
NM_000963
VERSION
NM_000963.3

This sequence information is just for reference only.

COX-2 cDNA / Gene Alias

  • COX2
  • cyclooxygenase 2
  • prostaglandin G / H synthase 2

COX-2 cDNA / Gene Expression

Biased expression in bone marrow (RPKM 59.3), urinary bladder (RPKM 41.1) and 11 other tissues